Maria Domenica Cappellini Selected Research

Deferasirox

1/2022	An open-label, multicenter, efficacy, and safety study of deferasirox in iron-overloaded patients with non-transfusion-dependent thalassemia (THETIS): 5-year results.
12/2021	Kidney Tubular Damage Secondary to Deferasirox: Systematic Literature Review.
1/2017	One-year results from a prospective randomized trial comparing phlebotomy with deferasirox for the treatment of iron overload in pediatric patients with thalassemia major following curative stem cell transplantation.
3/2015	Deferasirox effect on renal haemodynamic parameters in patients with transfusion-dependent β thalassaemia.
1/2015	Defining serum ferritin thresholds to predict clinically relevant liver iron concentrations for guiding deferasirox therapy when MRI is unavailable in patients with non-transfusion-dependent thalassaemia.
11/2014	Deferasirox for cardiac siderosis in β-thalassaemia major: a multicentre, open label, prospective study.
6/2013	Assessment and management of iron overload in β-thalassaemia major patients during the 21st century: a real-life experience from the Italian WEBTHAL project.
8/2012	Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study.
6/2012	Deferasirox for up to 3 years leads to continued improvement of myocardial T2* in patients with β-thalassemia major.
1/2012	Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: Results from the EPIC Clinical Trial.

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Maria Domenica Cappellini Research Topics

Disease

47	Thalassemia 06/2022 - 04/2005
44	Iron Overload 12/2021 - 10/2004
35	beta-Thalassemia (Cooley's Anemia) 10/2021 - 10/2004
19	Anemia 11/2021 - 06/2007
14	Sickle Cell Anemia (Hemoglobin S Disease) 06/2022 - 04/2005
11	Gaucher Disease (Gaucher's Disease) 12/2020 - 09/2007
8	Siderosis 01/2017 - 02/2002
6	Hemoglobinopathies 05/2022 - 04/2005
6	Exanthema (Rash) 01/2017 - 05/2006
5	Heart Diseases (Heart Disease) 01/2022 - 05/2006
5	Fibrosis (Cirrhosis) 01/2020 - 10/2004
5	Hemolytic Anemia 01/2019 - 10/2006
5	Infections 12/2017 - 08/2009
5	Osteoporosis 08/2016 - 08/2008
5	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 11/2015 - 02/2008
4	Erythropoietic Protoporphyria 03/2022 - 05/2005
4	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 01/2021 - 04/2015
4	Acute Intermittent Porphyria (Porphyria, Acute) 11/2016 - 07/2006
3	Disease Progression 06/2022 - 10/2010
3	Thrombocytopenia (Thrombopenia) 01/2021 - 08/2012
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 04/2015
3	Neoplasms (Cancer) 01/2019 - 02/2014
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018 - 12/2017
3	Metabolic Bone Diseases (Osteopenia) 08/2016 - 08/2008
3	Heart Failure 11/2015 - 10/2004
3	Porphyrias (Porphyria) 10/2010 - 08/2009
3	Hemosiderosis 04/2010 - 07/2006
2	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 12/2021
2	Lung Diseases (Lung Disease) 01/2022 - 01/2017
2	Congenital Hemolytic Anemia (Hemolytic Anemia, Congenital) 06/2021 - 01/2017
2	Splenomegaly 01/2021 - 08/2012
2	Iron-Refractory Iron Deficiency Anemia 12/2020 - 04/2015
2	Hemolysis 01/2020 - 01/2007
2	Hepatomegaly 01/2020 - 08/2012
2	Malaria 06/2019 - 10/2010
2	Thrombophilia 01/2018 - 11/2009
2	Cardiomyopathies (Cardiomyopathy) 09/2017 - 01/2009
2	Hepatitis 01/2017 - 10/2010
2	Cardiotoxicity 11/2015 - 04/2009
2	Refractory Anemia 11/2012 - 01/2011
2	Hypothyroidism 11/2011 - 08/2009
2	Pulmonary Hypertension 11/2011 - 04/2005
2	Thrombosis (Thrombus) 11/2011 - 10/2006
2	Cardiovascular Diseases (Cardiovascular Disease) 03/2011 - 05/2006
2	Virus Diseases (Viral Diseases) 10/2010 - 02/2002
2	Agranulocytosis (Granulocytopenia) 01/2009 - 05/2006

Drug/Important Bio-Agent (IBA)

60	IronIBA 01/2022 - 10/2004
24	Deferasirox FDA Link 01/2022 - 05/2006
22	Hemoglobins (Hemoglobin)IBA 06/2022 - 02/2014
18	Ferritins (Ferritin)IBA 12/2020 - 10/2004
11	Heme (Haem)IBA 03/2022 - 02/2002
11	EnzymesIBA 08/2020 - 02/2002
9	GlobinsIBA 05/2022 - 01/2018
9	Transferrin (beta 2 Transferrin)IBA 03/2022 - 01/2009
9	Chelating AgentsIBA 01/2017 - 05/2006
9	Deferoxamine (Desferal)FDA LinkGeneric 06/2013 - 10/2004
7	HepcidinsIBA 01/2019 - 09/2009
6	DeferiproneIBA 06/2013 - 05/2006
5	Fetal Hemoglobin (Hemoglobin F)IBA 06/2022 - 01/2012
4	LigandsIBA 12/2021 - 01/2019
4	luspaterceptIBA 12/2021 - 06/2021
4	Glucosylceramides (Glucocerebrosides)IBA 04/2017 - 11/2012
4	Insulin-Like Growth Factor I (IGF-1)IBA 08/2016 - 11/2007
3	Ferrochelatase (Heme Synthetase)IBA 03/2022 - 05/2005
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 11/2011
3	GlucosidasesIBA 01/2021 - 09/2014
3	metal transporting protein 1 (ferroportin)IBA 12/2020 - 09/2009
3	Glucosylceramidase (Glucocerebrosidase)IBA 01/2020 - 11/2012
3	Proteins (Proteins, Gene)FDA Link 05/2019 - 01/2007
3	Growth Differentiation Factor 15IBA 01/2017 - 12/2011
3	Somatomedins (Somatomedin)IBA 08/2016 - 11/2007
3	Alanine Transaminase (SGPT)IBA 06/2013 - 07/2002
3	CreatinineIBA 01/2011 - 05/2006
2	Activin Receptors (Activin Receptor)IBA 12/2021 - 06/2021
2	ferric carboxymaltoseIBA 01/2021 - 01/2020
2	GlycosphingolipidsIBA 01/2020 - 12/2014
2	Amino Acids FDA Link 01/2020 - 08/2010
2	Codon (Codons)IBA 04/2019 - 08/2010
2	Sickle HemoglobinIBA 01/2019 - 04/2011
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2017
2	Antiviral Agents (Antivirals)IBA 12/2017 - 10/2010
2	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2017 - 08/2009
2	5' Untranslated Regions (5' UTR)IBA 11/2016 - 10/2012
2	Growth Hormone (Somatotropin)IBA 08/2016 - 08/2008
2	Diphosphonates (Bisphosphonates)IBA 12/2014 - 07/2012
2	Hormones (Hormone)IBA 07/2014 - 08/2009
2	NucleotidesIBA 10/2012 - 08/2010
2	Pharmaceutical PreparationsIBA 08/2012 - 01/2011
2	beta-Globins (beta Globin)IBA 08/2010 - 10/2006
1	AntioxidantsIBA 05/2022
1	protoporphyrin IXIBA 03/2022

Therapy/Procedure

32	Therapeutics 01/2022 - 10/2004
16	Chelation Therapy (Therapy, Chelation) 11/2021 - 05/2007
7	Splenectomy 01/2019 - 10/2006
6	Blood Transfusion (Blood Transfusions) 01/2019 - 05/2006
3	Hematopoietic Stem Cell Transplantation 11/2021 - 05/2014
3	Enzyme Replacement Therapy 12/2020 - 01/2011
2	Transplantation 01/2019 - 08/2010
2	Stem Cell Transplantation 01/2018 - 01/2017
2	Drug Therapy (Chemotherapy) 01/2015 - 02/2014